Gene
pnkd
- ID
- ZDB-GENE-050208-278
- Name
- PNKD metallo-beta-lactamase domain containing
- Symbol
- pnkd Nomenclature History
- Previous Names
-
- im:7147352
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have hydroxyacylglutathione hydrolase activity. Predicted to be involved in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in paroxysmal nonkinesigenic dyskinesia 1. Orthologous to human PNKD (PNKD metallo-beta-lactamase domain containing).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7147352 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| paroxysmal nonkinesigenic dyskinesia 1 | Alliance | Paroxysmal nonkinesigenic dyskinesia 1 | 118800 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001279 | Metallo-beta-lactamase |
| Domain | IPR032282 | Hydroxyacylglutathione hydrolase, C-terminal domain |
| Domain | IPR035680 | Hydroxyacylglutathione hydrolase, MBL domain |
| Family | IPR017782 | Hydroxyacylglutathione hydrolase |
| Homologous_superfamily | IPR036866 | Ribonuclease Z/Hydroxyacylglutathione hydrolase-like |
Domain Details Per Protein
| Protein | Length | Hydroxyacylglutathione hydrolase | Hydroxyacylglutathione hydrolase, C-terminal domain | Hydroxyacylglutathione hydrolase, MBL domain | Metallo-beta-lactamase | Ribonuclease Z/Hydroxyacylglutathione hydrolase-like |
|---|---|---|---|---|---|---|
|
UniProtKB:F6NM08
|
361 |
Interactions and Pathways
No data available
Plasmids
No data available