ZFIN is now using GRCz12tu for Genomic Data
Gene
pnkd
- ID
- ZDB-GENE-050208-278
- Name
- PNKD metallo-beta-lactamase domain containing
- Symbol
- pnkd Nomenclature History
- Previous Names
-
- im:7147352
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable thiolester hydrolase activity. Predicted to act upstream of or within methylglyoxal catabolic process. Predicted to be located in membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in paroxysmal nonkinesigenic dyskinesia 1. Orthologous to human PNKD (PNKD metallo-beta-lactamase domain containing).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7147352 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| paroxysmal nonkinesigenic dyskinesia 1 | Alliance | Paroxysmal nonkinesigenic dyskinesia 1 | 118800 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001279 | Metallo-beta-lactamase |
| Domain | IPR032282 | Hydroxyacylglutathione hydrolase, C-terminal domain |
| Domain | IPR035680 | Hydroxyacylglutathione hydrolase, MBL domain |
| Family | IPR017782 | Hydroxyacylglutathione hydrolase |
| Homologous_superfamily | IPR036866 | Ribonuclease Z/Hydroxyacylglutathione hydrolase-like |
Domain Details Per Protein
| Protein | Additional Resources | Length | Hydroxyacylglutathione hydrolase | Hydroxyacylglutathione hydrolase, C-terminal domain | Hydroxyacylglutathione hydrolase, MBL domain | Metallo-beta-lactamase | Ribonuclease Z/Hydroxyacylglutathione hydrolase-like |
|---|---|---|---|---|---|---|---|
| UniProtKB:F6NM08 | InterPro | 361 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers